PESQUISA
Organic Synthesis
We are a group interested in exploring organic synthesis, developing methodologies, improving processes to make them more efficient, economical and environmentally more interesting. In this way, we have a special focus on employing catalysis in organic reactions, in addition to studying new energy sources such as microwaves and ultrasound.
We use organic synthesis to prepare molecules with potential applications in medicinal chemistry, organometallic chemistry and materials chemistry.
Organometallics
With regard to organometallics, we seek to contribute to the development of organoboron chemistry, especially boronic acids and their derivatives. Boronic acids and their derivatives find applications as chemical sensors, as ligands in boronate affinity chromatography or in boronate affinity electrophoresis, in boron neutron capture therapy. Recently, the medicinal chemistry of boron has attracted a lot of interest. Our group works to develop this potential of organoborons .
We are also very interested in the catalytic processes for C-C bond formation in which organometallic palladium species are involved.
Medicinal Chemistry
Medicinal chemistry is one of the central areas in which organic synthesis can be applied. It is the design, synthesis and biological evaluation of the prepared molecules in order to obtain bioactive compounds upon which optimizations can be made to obtain drugs for specific targets. In our research group, we are involved in the preparation, by organic synthesis, of molecules to be evaluated for cancer, inflammation, tuberculosis and neglected diseases.
Our work is developed in collaboration with other research groups that support us with molecular modeling studies and in vitro and in vivo assays for the biological targets of interest.